FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
نویسندگان
چکیده
منابع مشابه
FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Complex organisms require tissue-specific transcriptional programs, yet little is known about how these are established. The transcription factor FoxA1 is thought to contribute to gene regulation through its ability to act as a pioneer factor binding to nucleosomal DNA. Through genome-wide positional analyses, we demonstrate that FoxA1 cell type-specific functions rely primarily on differential...
متن کاملFOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function
Forkhead box A1 (FOXA1) is an FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically, this involve...
متن کاملDynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states.
Cellular differentiation is orchestrated by lineage-specific transcription factors and associated with cell type-specific epigenetic signatures. In the present study, we used stage-specific, epigenetic "fingerprints" to deduce key transcriptional regulators of the human monocytic differentiation process. We globally mapped the distribution of epigenetic enhancer marks (histone H3 lysine 4 monom...
متن کاملA Novel Approach to Assay DNA Methylation in Prostate Cancer
Forkhead box A1 (FOXA1) is an FKHD family pro-tein that plays pioneering roles in lineage-specificenhancer activation and gene transcription. Throughgenome-wide location analyses, here we show thatFOXA1 expression and occupancy are, in turn, re-quired for the maintenance of these epigeneticsignatures, namely DNA hypomethylation and his-tone 3 lysine 4 methylation. Me...
متن کاملAntisense Translates into Sense
T he paradigm that DNA is the central bank of genetic information within the cell, and that portions of the DNA are copied via transcription to RNA, which is subsequently decoded to synthesize protein in a cell, is basically true throughout cellular evolution. However, it is also true that although this is a general blueprint for regulating how genes are expressed, evolution, with its varied se...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.01.018